GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | CENPQ | chr6:49431096-49460820:+ | -0.3 | -6.07 | 3.05E-9 | Folate pathway vitamin levels |
| BLCA | cis | rs9473555 | 1 | rs4715130 | chr6:49416825 | MUT | chr6:49398994-49431031:- | 0.25 | 4.96 | 1.07E-6 | Folate pathway vitamin levels |
| BLCA | cis | rs1474698 | 1 | rs4715590 | chr6:56060017 | COL21A1 | chr6:55921389-56258892:- | 0.32 | 5.77 | 1.68E-8 | Pulse pressure |
| BLCA | cis | rs2243480 | 1 | rs4718269 | chr7:65200778 | CCT6P1 | chr7:65216092-65228661:+ | -0.3 | -4.21 | 3.16E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718270 | chr7:65202407 | CCT6P1 | chr7:65216092-65228661:+ | 0.32 | 4.44 | 1.18E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718309 | chr7:65627764 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718315 | chr7:65648541 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718316 | chr7:65648731 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.71 | 3.52E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718317 | chr7:65648901 | CCT6P1 | chr7:65216092-65228661:+ | -0.33 | -4.46 | 1.07E-5 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718333 | chr7:65772758 | CCT6P1 | chr7:65216092-65228661:+ | -0.35 | -4.72 | 3.24E-6 | Diabetic kidney disease |
| BLCA | cis | rs2243480 | 1 | rs4718334 | chr7:65789454 | CCT6P1 | chr7:65216092-65228661:+ | -0.36 | -4.92 | 1.29E-6 | Diabetic kidney disease |
| BLCA | cis | rs11976180 | 1 | rs4726669 | chr7:143758191 | ARHGEF35 | chr7:143883677-143892736:- | -0.34 | -5.97 | 5.56E-9 | Obesity-related traits |
| BLCA | cis | rs4727443 | 1 | rs4727443 | chr7:99593346 | TRIM4 | chr7:99488037-99517154:- | -0.23 | -4.09 | 5.18E-5 | Interstitial lung disease |
| BLCA | cis | rs4728142 | 1 | rs4728142 | chr7:128573967 | IRF5 | chr7:128577769-128590086:+ | 0.24 | 4.4 | 1.44E-5 | Systemic lupus erythematosus;Ulcerative colitis;Inflammatory bowel disease |
| BLCA | cis | rs477692 | 1 | rs473073 | chr10:131429646 | MGMT | chr10:131265454-131565783:+ | 0.23 | 4.93 | 1.25E-6 | Response to temozolomide |